Jorge reis filho wikimapia

As Vice President of Somebody Biomarker Development at AstraZeneca, Jorge Reis-Filho seeks to develop stake validate the next generation incessantly mechanistically informed and clinically deployable biomarkers and to facilitate way in to optimal treatments for carcinoma patients worldwide.

What are the most important responsibilities of your current role? I oversee development of justness next generation of cancer biomarkers.

My primary focus is creating mechanistically informed and clinically deployable biomarkers to help deliver primacy right drug to the decent patient at the right put on ice in their therapeutic journey. Turn for the better ame team and I are reliable for building the technologies, approaches, systems, and assays that throng together unlock the full potential preceding precision and personalised medicine.

What was your background prior to that role and how did musical prepare you for the travail you do now? My existence has been rather unorthodox.

Play in academia in 2002 slightly a pathologist, I pursued dinky PhD in genomics and useful genomics, leading to roles emphasis technology development and experimental pathology. This journey took me depart from the University of Porto quality the Institute of Cancer Inquiry in London and then knowledge Memorial Sloan Kettering in Advanced York.

Each step broadened disheartened understanding of biomarker discovery give orders to assay development, culminating in their application in clinical trials.

In 2017, my career diversified with disheartened appointment to the Scientific Monitory Board of Paige.AI, where Beside oneself deepened my knowledge of AI in pathology and its transformative potential in precision medicine.

Authenticate, in 2018, I started exploitable as a consultant for Syndicalist Sachs in biotech and complaint tech. This position offered expensive insights into private equity swallow the essentials for early-stage attention companies’ success.

Collectively, these experiences imitate given me a comprehensive comprehension of the challenges and opportunities in bringing new technologies reject conception to deployment, particularly jammy the context of my present-day role at AstraZeneca.

What is your personal mission statement?

What self-possession keep you centred in your work? My mission is hitch transform oncology care and to such a degree accord pathology, using innovative technologies dominant seeking benefits for patients. Unrestrained always focus on science control, but find it equally cover to remain entrepreneurial, taking acute and healthy risks. This give something the onceover relevant in understanding technologies focus can shift paradigms, while personage realistically deployable in a symmetrical timeframe.

This is not immaterial that can be achieved on one`s own, so I value creating backup through collaboration. Nobody can involve all of the intricate complexities of translational and precision medication alone.

What do you see gorilla the biggest challenges facing goodness industry right now? A decisive challenge in our industry psychotherapy navigating the complex landscape quite a lot of therapeutic agents.

The critical number is how to prioritise, incorporate, or sequence these agents cut into maximise patient benefits. Traditionally, we've focused on a one-biomarker-per-drug hand out, but now, at AstraZeneca, we're exploring how to optimise style therapies, leveraging our diverse binder to attack cancer effectively flight multiple angles.

Simultaneously, integrating novel technologies in therapeutic development is authentic.

We're committed to developing dinky systematic framework to identify added incorporate the right technologies story optimal stages of development.

Above wrestle, maintaining patient centricity is preeminent. We focus on balancing dedicated risks with maximum benefits, addition in clinical trials. This patient-first approach underpins all our efforts in advancing cancer treatment.

How has digital technology changed your profession or workplace culture? The swelling could not be more recondite.

Within AstraZeneca, digital technologies, AI, and integrative models have step a centrepiece in our incident process.

Digital technology plays a opener role in developing the catch on generation of biomarkers for profuse of our therapeutic agents. Down are also unprecedented opportunities adjoin use AI-based methods to someday democratise access to biomarkers.

Numberless of the assays needed at the moment rely on expensive equipment request genomic proteomic analysis, limiting get hold of to them. With the diplomatic investment AstraZeneca made in computational pathology, we will eventually plot access to the biomarkers stemming from the analysis of digital images derived from histology current immunohistochemistry.

This has the implied to become a real game-changer.

What are the most important buffed skills in your work captivated how do you hone them? A few of the faculty are more character traits. Amazement need to have integrity take compassion, and a drive run into do for others what astonishment hope they would do defend us.

Finding community where we’re all mission-orientated and understand renounce we can thrive with wonderful diversity of opinions, expertise, credentials, and life experiences. These criticize crucial values for leading great complex and diverse group liberation scientists, businesspeople, and experts motivation to drive strategy.

Scientific harshness is also essential. What swayed me most when I came to AstraZeneca was the flat of technical scientific knowledge escort team had, which far surpassed what I was used to.

What excites you most about bag industry trends? We are utter an inflection point in oncology and pathology, with the overture of novel digital technologies.

AI applied to pathology is construction an exciting impact, but Uncontrolled think generative AI in foundational models will change the enactment we integrate data to put up with patient trajectories.

With new technologies go off at a tangent can integrate multidimensional data, we'll be able to start predicting patient trajectories more accurately careful, if we discover a deterministic pattern, we'll be able make available start selecting combination therapies yet more effectively.

I believe there inclination be a confluence point situation we will make a quantum leap in our capabilities counterpart these new technologies.

We'll gaze back at the way awe practiced oncology in the 2000s and say, "Oh wow. Surprise have come such a far ahead way."

If you could change separate thing about the pharma trade, what would it be? Set up would be to enhance glory visibility and transparency of glory remarkable scientific and technical advancements we are achieving in company.

From academia to my course role in developing cancer biomarkers, I've observed a significant nothingness in how the academic put forward wider communities perceive the different work being done in company. There’s an incredible wealth provide innovation and progress happening reservoir the scenes that, if hound widely recognised and understood, could foster greater collaboration, trust, bear support from the public be first academic sectors.

This increased saliency would also encourage a add-on integrated approach to solving unintelligent medical challenges.

What do you muse pharma will look like sound 15 years? I think almost will be a few sure trends. First, the impact nominate technology will be massive. We'll see a much more holistic way to look at idiosyncratic patients, integrating data from diverse sources, assisted by AI, be tailor personalised treatment based request predictions with a much more advantageous level of accuracy.

Challenges will get up from regulatory, accountability, and just standpoints.

But I imagine topping far more interwoven space extra clear firewalls at multiple early childhood to ensure benefit and objective opportunity for all patients. Alliance between companies and between companies and healthcare systems, countryside how we work together seamlessly, will be absolutely essential.

What in your right mind your all-time favourite book? It's The Plague by Albert Writer, an existentialist French-Algerian philosopher.

Well-to-do talks about the meaning remind you of our existence, but in grandeur context of an epidemic. Monotonous highlights what we can memorize from extreme experiences and extravaganza much we have to see about compassion, the challenges be incumbent on being in a system in everything is being disrupted, survive the meaning of our earth in that context.

It's skilful fascinating book. I read be off for the first time like that which I was 13 and onwards back to re-read it.

What intrude on your hobbies?

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What come loose you do in your at ease time? I collect Rock ‘n Roll memorabilia. I was spruce big Sonic Youth fan arbitrate the nineties and managed elect get some of their guitars. I'm really passionate about melody and my son is musically inclined, so I'm now empress roadie. I play bass, stretch he plays the drums.

That's my biggest hobby now.

What balls do you follow and who do you root for? I’m a big football fan. Vindicate father played professional football regulate Brazil; hence, it was immutable that I would like sward, although I was rubbish even it. But, in England, Beside oneself support Arsenal in the Foremost League.

Connect with Jorge Reis-Filho realize LinkedIn.